Megaloblastic anaemia due to trimethoprim-sulphamethoxazole therapy in uraemia.
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چکیده
منابع مشابه
Toxicity of co-trimoxazole in nutritional haematinic deficiency.
Introduction Co-trimoxazole is an antibacterial combination of trimethoprim and sulphamethoxazole which acts by sequentially blockading folate metabolism (Elion, Singer & Hitchings, 1954; Darrell, Garrod & Waterworth, 1968). Cases of haematological toxicity have been reported following its use in patients with initially normal haematological status (Kahn, Fein & Brodsky, 1968; Paulley, 1970; Mc...
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Introduction Co-trimoxazole is an antibacterial combination of trimethoprim and sulphamethoxazole which acts by sequentially blockading folate metabolism (Elion, Singer & Hitchings, 1954; Darrell, Garrod & Waterworth, 1968). Cases of haematological toxicity have been reported following its use in patients with initially normal haematological status (Kahn, Fein & Brodsky, 1968; Paulley, 1970; Mc...
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The platelet ascorbic acid concentration was measured in 26 normal subjects and found to be 20 times as high as in plasma. This is in agreement with previous reports in the literature. The platelets of patients with uraemia, leukaemia, and megaloblastic anaemia had a lower than normal platelet ascorbic acid content. In uraemia and megaloblastic anaemia the plasma ascorbic acid concentration was...
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In a clinical trial on 220 patients with bacteriologically proved enteric fever trimethoprim-sulphamethoxazole was compared with chloramphenicol. All patients in both groups responded, and the mean periods of defervescence after starting therapy were similar in both groups. Trimethoprim-sulphamethoxazole was much superior to chloramphenicol in rapidity and uniformity of relief of toxaemia. "Tox...
متن کاملPartial villous atrophy in nutritional megaloblastic anaemia corrected by folic acid therapy.
A patient with megaloblastic anaemia due to nutritional folate deficiency is described. Partial villous atrophy and malabsorption of xylose showed progressive improvement to normal with folic acid therapy.
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 49 568 شماره
صفحات -
تاریخ انتشار 1973